NCT05033041

Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide

Comparison of Gastric Volumes by Gastric Ultrasound in Term Parturients Undergoing Scheduled Elective Cesarean Delivery With and Without Metoclopramide

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Our objective is to compare gastric volumes (mL) between women who receive metoclopramide versus placebo prior to scheduled cesarean delivery in appropriately fasted patients. If metoclopramide is found not to reduce gastric volumes this would inform future practice guidelines for obstetric anesthesia, which currently recommends metoclopramide administration prior to cesarean deliveries. We hypothesize that metoclopramide given to women with appropriate fasting prior to cesarean delivery does not result in any clinically significant reduction in gastric volume (mL) and therefore does not provide any additional benefit for aspiration prophylaxis but may expose patients to unnecessary side effects. A secondary objective will be to evaluate if gastric volume is a significant predictor of intraoperative nausea and vomiting.

Conditions

• Pregnancy
• Cesarean Section
• Aspiration

Interventions

Type	Name	Description
DRUG	Study drug metoclopramide	Intravenous administration of 10 mg metoclopramide
DRUG	Study drug placebo administration	Intravenous administration of placebo (sterile normal saline)

Timeline

• Start date: 2021-10-20
• Primary completion: 2024-01-30
• Completion: 2024-02-08
• First posted: 2021-09-02
• Last updated: 2025-09-11
• Results posted: 2025-05-08

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study