NCT05031663

Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study

Effect of Daily Consumption of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Middle -Aged Men: A Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 61 (actual)
• Sponsor: Loma Linda University · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This research study will test the effects of almonds on immune functions and immune response to influenza vaccine in overweight middle-aged men and postmenopausal women

Detailed description

The proposed study is a parallel-group, free-living, observer-blind, randomized controlled dietary intervention trial on 66 overweight middle-aged men and post menopausal women. This study will be carried out in two phases: Phase 1 will examine the effects of almonds on clinically relevant markers of immune function, and Phase 2 will assess the antibody response to influenza vaccination following almond consumption. Participants will attend a baseline clinic and will be randomized to one of two groups. The Almond group will receive 15% of daily energy intake in the form of almonds as a snack and the Control group will continue thier usual diet but completely avoid almonds and restrict other nuts to less than 2 servings per week. The intervention will be for 12 weeks, at which time both group participants will receive the influenza vaccination, and continue the same dietary intervention for another 28 weeks.

Conditions

• Immune Response
• Inflammation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Almond group	Participants in the Almond group will receive 15% of their daily energy intake in the form of almonds as a snack
DIETARY_SUPPLEMENT	Control Group	The control group will continue their usual diet but will completely avoid almonds and restrict other nuts to less than 2 servings per week

Timeline

• Start date: 2021-08-12
• Primary completion: 2023-05-10
• Completion: 2023-05-10
• First posted: 2021-09-02
• Last updated: 2025-12-09

Locations

1 site across 1 country: United States