NCT05031065

Prognostic Indicators for Radiation-induced Breast Fibrosis

Identifying Prognostic Indicators for the Development of Radiation-induced Breast Fibrosis

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 4 (actual)
• Sponsor: AHS Cancer Control Alberta · Academic / Other
• Sex: Female
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma.

Detailed description

To study the inflammatory response during and after radiotherapy, especially by measuring the concentration of an enzyme called autotaxin and its product LPA in the blood plasma. Autotaxin and LPA cause fibrosis in other situation, but they have not been tested in radiation-induced fibrosis. We will determine if the duration and magnitude of the autotaxin and LPA responses are prognostic for the 15-28% of patients who will develop fibrosis. This fibrosis will be detected by ultrasound and a novel application of elastography, which should provide much earlier and quantifiable fibrotic changes compared to conventional physical examination.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	Breast Cancer Radiotherapy	4000-4250 cGy in 15-16 daily fractions

Timeline

• Start date: 2024-01-24
• Primary completion: 2025-05-05
• Completion: 2025-05-05
• First posted: 2021-09-01
• Last updated: 2025-06-27

Locations

1 site across 1 country: Canada