NCT05024916

Blueberry Intervention Study for Brain Aging

The Effect of Blueberry Consumption on Brain Health in Older Adults: in Vivo Measures of Cerebral Antioxidant and Cerebral Blood Flow

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 65 Years – 89 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine if increased blueberry intake helps increase brain antioxidant (glutathione) and cerebral blood flow in older adults.

Detailed description

Consuming blueberries may improve brain health of older adults by increasing the antioxidant levels in the brain to protect nerve cells in the aging brain. Researchers think that there may be a relationship between the brain's antioxidant defense system and blueberry intake due to the high antioxidant content in blueberries. This study will investigate if blueberry intake may aid in enhancing glutathione levels and cerebral blood flow using special Magnetic Resonance Imaging (MRI) scans. Participants will be asked to make a total of up to 4 visits to the research site. Participation will last about 3 months.

Conditions

• Brain Aging

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Intervention	26 g packets of freeze-dried blueberries (equivalent to 1 cup of fresh blueberries) will be given to participants to be consumed daily. Participants will be asked to consume 1 packet per day for 3 months.
DIETARY_SUPPLEMENT	Control	26 g packets of isocaloric carbohydrate-matched powder will be given to participants to be consumed daily. Participants will be asked to consume 1 packet/day for 3 months.

Timeline

• Start date: 2022-06-01
• Primary completion: 2024-10-03
• Completion: 2024-10-03
• First posted: 2021-08-27
• Last updated: 2025-05-21

Locations

1 site across 1 country: United States