NCT05020405

The Effect of Simvastatin With Guided Bone Regeneration in Ridge Splitting and Simultaneously Implantation

The Effect of Simvastatin With Guided Bone Regeneration on Ridge Volume in Ridge Splitting and Simultaneously Implantation: a Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Ridge split augmentation technique, with immediate implant placement, reduces the time of the treatment and the time of the final prosthetic reconstruction. Furthermore, compression of the bone increases its density. SMV is also found to promote osteogenic differentiation of bone marrow stem cells, suppress osteoclastic differentiation in bone tissue, and promotes osseointegration around implants in animal studies. The aim of this study is to compare surgical outcomes of the application of the alveolar ridge splitting (ARS) in combination with guided bone regeneration (GBR) using bone grafting and a barrier membrane, associated with immediate implant placement versus ARS in combination with the use of SMV with GBR using bone grafting and a barrier membrane, associated with immediate implant placement in patients with horizontally atrophic jaw bones.

Conditions

• Ridge Splitting
• Simvastatin
• Immediate Implant

Interventions

Type	Name	Description
PROCEDURE	Immediate implant placement and ARS with GBR and SMV	Implant insertion and GBR for augmentation of the gap between buccal and lingual plate using bone graft mixed with SMV
PROCEDURE	Immediate implant placement and ARS with GBR	Implant insertion and GBR for augmentation of the gap between buccal and lingual plate

Timeline

• Start date: 2020-10-01
• Primary completion: 2022-02-12
• Completion: 2022-02-20
• First posted: 2021-08-25
• Last updated: 2023-07-18

Locations

1 site across 1 country: Egypt