NCT05018364

Serum Erythropoietin Level in Perinatal Asphyxia

Serum Erythropoietin Level for Detection of Kidney and Brain Injuries in Asphyxiated Neonates in Neonatal Intensive Care Unit.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 1 Day – 4 Days
• Healthy volunteers: Accepted

Summary

This study is to evaluate brain and kidney injuries in full-term neonates with perinatal asphyxia by detecting specific biomarker in blood (Erythropoietin).

Detailed description

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Acute kidney injury (AKI) occurs in (50 - 72%) among asphyxiated term infants. The kidney cells that make erythropoietin are sensitive to low oxygen levels in the blood that travels through the kidney. These cells make and release erythropoietin when the oxygen level is too low.

Conditions

• Perinatal Hypoxia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum erythropoietin level	Evaluate serum erythropoietin level in neonates exposed to hypoxia compared to control group

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-06-01
• Completion: 2021-06-15
• First posted: 2021-08-24
• Last updated: 2021-08-30

Locations

1 site across 1 country: Egypt