NCT05017896

Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 242 (estimated)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Conditions

• Aneurysm, Dissecting
• Acute Kidney Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Normal CT Renal Perfusion imaging indexes	A CT imaging which indicates the status of renal perfusion is normal.
DIAGNOSTIC_TEST	Low CT Renal Perfusion imaging indexes	A CT imaging which indicates the status of renal perfusion is low.

Timeline

• Start date: 2021-09-01
• Primary completion: 2023-01-01
• Completion: 2023-02-01
• First posted: 2021-08-24
• Last updated: 2021-08-24