NCT05016128

Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

Second Affiliated Hospital Zhejiang University School of Medicine

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 92 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine，which is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after video-assisted thoracic surgery.

Conditions

• Postoperative Hyperalgesia

Interventions

Type	Name	Description
DRUG	S-ketamine	S-ketamine is used for preventing postoperative hyperalgesia,thus reducing the patient's acute postoperative pain
DRUG	saline	saline is used for control

Timeline

• Start date: 2021-08-17
• Primary completion: 2021-12-30
• Completion: 2022-04-30
• First posted: 2021-08-23
• Last updated: 2021-09-29

Locations

1 site across 1 country: China