NCT05012813

Humidified Forest Oils for Immune System Recovery in Stage I-III Breast or Prostate Cancer

Feasibility of Substitution of Volatile Organic Compound Humidification to Simulate the Forest Experience Effects on Immune System Recovery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: OHSU Knight Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial studies the feasibility of simulating forest therapy using humidified wood or fragrant oils, in improving immune cells, like natural killer cells, number and activity, and their downstream proteins, perforin and granulysin in patients with stage I-III breast or prostate cancer who completed chemo- and/or radiation therapy. The knowledge gained from this study may help cancer patients who have compromised immune systems and who also cannot participate in outdoor activities like exercise or forest walks.

Detailed description

PRIMARY OBJECTIVE: I. Determine the feasibility of using humidified phytoncides to simulate the forest greenspace immersion (simulated forest immersion therapy \[SFIT\]) in cancer patients with solid tumor who have completed surgery, chemo- and radiation therapy as an alternate method of access to the natural forest greenspace. SECONDARY OBJECTIVE: I. Determine the feasibility of collecting and analyzing immune system measures while deploying the simulated forest immersion therapy with forest oils (SFIT), as well as measuring natural killer (NK) cell number and activity, and perforin and granulysin. OUTLINE: Patients participate in SFIT, using humidified wood and fragrance oils, over 1 hour on day 1, day 3 or 4 and on day 7. Patients also undergo blood sample collection at baseline and on days 3 or 4 and 7 and participate in interviews at baseline and post-treatment.

Conditions

• Breast Carcinoma
• Prostate Carcinoma

Interventions

Type	Name	Description
OTHER	Aromatherapy with Essential Oils	Participate in SFIT this is one intervention with aroma therapy with essential Forest oils

Timeline

• Start date: 2022-07-19
• Primary completion: 2025-02-28
• Completion: 2025-03-31
• First posted: 2021-08-19
• Last updated: 2026-03-09

Locations

1 site across 1 country: United States