NCT05011981

Hemostatic Activity Following LAAO

Hemostatic Activity Following Left Atrial Appendage Occlusion

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 135 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The primary objective of this study is to prospectively investigate hemostatic activity following transcatheter left atrial appendage occlusion (LAAO).

Detailed description

This is a prospective cohort study of patients undergoing transcatheter LAAO at Aarhus University Hospital. Hemostatic consequences following device implantation will be evaluated using blood samples collected pre- and post-procedurally, and serially during three months follow-up in 135 LAAO patients. Platelet function and characteristics, overall activation of the extrinsic coagulation pathway and the intrinsic contact activation pathway, as well as endothelial response to implantation, will be assessed through a wide range of biochemical analyses. Patients will serve as their own controls, with a final control blood sample collected at three-months follow-up.

Conditions

• Atrial Fibrillation
• Stroke

Interventions

Type	Name	Description
DEVICE	Left Atrial Appendage Occlusion	Interventional left atrial appendage occlusion with the Amulet or Watchman device

Timeline

• Start date: 2021-10-11
• Primary completion: 2024-07-01
• Completion: 2024-12-01
• First posted: 2021-08-18
• Last updated: 2024-01-11

Locations

1 site across 1 country: Denmark