Trials / Recruiting
RecruitingNCT05011045
Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (estimated)
- Sponsor
- M.D. Anderson Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hematologic malignancies). This may help researchers learn more about the effects of whole brain radiation therapy on memory and thinking in patients with blood cancer.
Detailed description
PRIMARY OBJECTIVE: I. Record patients' cognitive outcomes after whole-brain radiation therapy (WBRT) for hematologic malignancies using standard-of-care neurocognitive function testing. SECONDARY OBJECTIVES: I. Assess patients' quality-of-life after WBRT for hematologic malignancies, based on a validated questionnaire. II. Explore magnetic resonance imaging (MRI) changes in the brain after WBRT for hematologic malignancies, based on standard-of-care imaging studies. III. Study the role of Memantine in patients' cognitive outcomes during and after WBRT for hematologic malignancies, based on standard-of-care use, utilizing standard-of-care neurocognitive function testing. OUTLINE: Patients undergo neurocognitive function assessments, complete questionnaires over 8-10 minutes and undergo standard of care MRI at baseline (within 4 weeks before the first day of WBRT), 2, 6, 12 months after RT completion, then annually for 5 years.
Conditions
- Central Nervous System Lymphoma
- Hematopoietic and Lymphoid Cell Neoplasm
- Leukemia
- Lymphoma
- Plasma Cell Myeloma
- Secondary Central Nervous System Lymphoma
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Magnetic Resonance Imaging | Undergo MRI |
| OTHER | Neurocognitive Assessment | Undergo neurocognitive function assessment |
| OTHER | Quality-of-Life Assessment | Complete questionnaires |
| OTHER | Questionnaire Administration | Complete questionnaires |
Timeline
- Start date
- 2020-01-09
- Primary completion
- 2026-10-31
- Completion
- 2026-10-31
- First posted
- 2021-08-18
- Last updated
- 2025-11-10
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05011045. Inclusion in this directory is not an endorsement.