Trials / Recruiting
RecruitingNCT05010031
A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change
Phase II Study to Examine Precision Radiation in Patients With Pathogenic Mutations in ATM
- Status
- Recruiting
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- Memorial Sloan Kettering Cancer Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would still be effective to treat these tumors.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| RADIATION | Palliative radiotherapy | An initial cohort of 12 evaluable patients will be treated with 4Gyx2, with adaptive dosing planned for expansion cohorts pending the number of failures observed after 6 month observation of the initial cohort. |
Timeline
- Start date
- 2021-08-11
- Primary completion
- 2027-08-01
- Completion
- 2027-08-01
- First posted
- 2021-08-18
- Last updated
- 2026-01-23
Locations
7 sites across 1 country: United States
Source: ClinicalTrials.gov record NCT05010031. Inclusion in this directory is not an endorsement.