NCT05008588

Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct

Safety and Efficacy of Combined Conditioned Medium With Umbilical Cord Mesenchymal Stem Cells as A Novel Strategy for Acute Stroke Infarct

• Status: Active Not Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: PT. Prodia Stem Cell Indonesia · Industry
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in acute stroke patients to induce neurogenesis.

Detailed description

This study has 3 arms namely CM and UC-MSCs treatment, UC-MSCs treatment only, and control. The investigator hypothesized that group of CM and UC-MSCs combination is the optimal treatment to induce neurogenesis in stroke patients.

Conditions

• Ischemic Stroke

Interventions

Type	Name	Description
BIOLOGICAL	Conditioned Medium	Intranasal of 3 cc of conditioned medium each, for 3 days in a row
BIOLOGICAL	Umbilical Cord Mesenchymal Stem Cells	Intra-parenchymal transplantation of 20x10\^6 UC-MSCs
PROCEDURE	Neurologic and Neutrophic Drugs	Such as clopidogrel, piracetam, citicoline

Timeline

• Start date: 2022-05-30
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2021-08-17
• Last updated: 2026-02-25

Locations

2 sites across 1 country: Indonesia