NCT05007223

Skin Microbiome Profile in Hailey-Hailey Disease

Characterization and Analysis of the Skin Microbiome in Hailey-Hailey Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: Gangnam Severance Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Accepted

Summary

"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion. The characteristic of this disease is the involvement of intertriginous areas of the skin, which are the moist sites including the axillary vault and the inguinal crease. The composition of microbial communities is primarily dependent on the physiology of the skin site and the moist sites have distinct compositions of skin microorganisms. In addition, treatment with doxycycline is often helpful in the management of Hailey-Hailey disease. These findings suggest a role of the skin microbiome in the pathogenesis of Hailey-Hailey disease. The purpose of this study is to characterize the skin microbiome in patients with Hailey-Hailey disease by the 16S method, to better understand the pathogenesis of the disease and to discover new therapeutic targets in the future.

Detailed description

Investigators will look at patients with Hailey-Hailey disease, and healthy controls. Investigators will look at skin microbiome (Bacterial diversity and the relative abundance of major bacterial taxa) Investigators will assess this in patients with Hailey-Hailey disease before and after doxycycline and compare them to healthy controls.

Conditions

• Hailey-Hailey Disease

Interventions

Type	Name	Description
DRUG	Doxycycline	200mg/day for 28 days(Given doxycycline to patients with Hailey-Hailey disease)

Timeline

• Start date: 2020-05-08
• Primary completion: 2020-09-18
• Completion: 2020-09-18
• First posted: 2021-08-16
• Last updated: 2021-08-16

Locations

1 site across 1 country: South Korea