NCT05006638

Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity

Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity: A Randomized Controlled Trial In Poison Control Center Of Ain Shams University Hospitals

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 62 (estimated)
• Sponsor: Aya Sabry Mohamed Mohamed · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Intravenous lipid emulsion is an established, effective treatment for local anesthetic systemic toxicity. It is also efficacious in animal models of severe cardiotoxicity caused by a number of other medications. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs. The present study will focus on the potential role of intravenous lipid emulsion as an adjuvant therapy in pesticides toxicity.

Conditions

• Pesticide Poisoning

Interventions

Type	Name	Description
DRUG	Lipid Emulsion, Intravenous	Lipid emulsion is a mixture of soybean oil, egg phospholipids, glycerine, and is available in 10%, 20%, and 30% strengths. It has been used for decades as parenteral nutrition and for caloric supplementation and essential fatty acid deficiency. It has also been used as a carrier for lipid soluble medications
DRUG	Atropine	a drug used as an antidote for some types of pesticides
DRUG	Toxogonin	a drug used as an antidote for some types of pesticides
DRUG	Sodium Bicarbonate Powder and ondansetron	standard of care for treatment of aluminuim phosphide is provided for patients poisoned with aluminuim phosphide

Timeline

• Start date: 2022-12-01
• Primary completion: 2023-06-01
• Completion: 2023-12-01
• First posted: 2021-08-16
• Last updated: 2022-08-16

Locations

1 site across 1 country: Egypt