NCT05005494

Hypnotic and Anti-nociceptive Components of Magnesium

Study of the Hypnotic and Anti-nociceptive Components of Magnesium Using Electroencephalogram Spectral Entropy and Pupillometry During Total Intravenous General Anaesthesia

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Liege · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol.

Detailed description

The aim of our study is to evaluate the effect of magnesium on the hypnotic effect of propofol. To achieve this, the investigators will analyse the effect of magnesium on the brain concentrations of propofol required to achieve a State Entropy value between 50-60, which corresponds to the recommended depth of anaesthesia. Our study will also evaluate the intraoperative anti- nociceptive effect of magnesium using pupillometry and its two indices, PPI and PRD

Conditions

• Anesthesia

Interventions

Type	Name	Description
DRUG	Magnesium sulfate IV	Infusion of magnesium sulphate 50 mg/kg (eq. 0.5ml/kg of magnesium sulphate 100mg/ml)
DRUG	Placebo	Infusion of NaCl (sodium chloride) 0.9% (placebo eq. 0.5ml/kg of NaCl 0.9%)

Timeline

• Start date: 2021-09-01
• Primary completion: 2021-11-01
• Completion: 2021-12-01
• First posted: 2021-08-13
• Last updated: 2021-08-19

Locations

1 site across 1 country: Belgium