NCT05004935

The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration

Analysis of Electromyography Activation Trunk Muscles and the Effect of Beetroot Juice Intake on the Results in Strength Exercises: Lateral Medicine Ball Throw and Sled Pushing

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Poznan University of Physical Education · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration. A secondary aims: exploring the effect of circulating trimethylamine N-oxide modification on plasma total antioxidant status, and measurement of changes in the skin nicotinamide-adenine dinucleotide reduced form (NADH) content during transient ischemia and reperfusion.

Detailed description

In a random order subjects will consume beetroot juice (140ml), or equimolar nitrates (NaNO3). Antecubital vein blood samples will be taken at the beginning, and every hour for 4 hours following consumption. Plasma trimethylamine N-oxide, total antioxidant status, and nitrite/nitrate concentrations will be determined. Using Flow Mediated Skin Fluorescence skin NADH content determined during controlled ischemia triggered by total occlusion of the brachial artery by the brachial blood pressure cuff and during reperfusion after deflation of the blood pressure cuff 2 and 4 hours following consumption.

Conditions

• Hypertension

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	beetroot juice	single intake of beetroot juice containing 800mg nitrates
OTHER	nitrate	single intake of 800mg nitrates

Timeline

• Start date: 2021-09-01
• Primary completion: 2023-12-01
• Completion: 2023-12-15
• First posted: 2021-08-13
• Last updated: 2023-11-15

Locations

1 site across 1 country: Poland