NCT05000112

Vaginal Microbiome-host Interaction in Mesh Exposure After TVM Surgery

The Influence of Vaginal Microbiome-host Interaction in the Mechanism of Mesh Exposure After Trans-Vaginal Mesh Implantation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: Female
• Age: 45 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Transvaginal pelvic mesh implantation（TVM） is a foreign body implantation operation with intraoperative colonization of vaginal bacteria. However, the vaginal microbiome-host interaction and its influence in the mechanism of mesh exposure after TVM remains unclear. This study will enroll post-TVM patients with and without mesh exposure and use their vaginal swabs to perform TRACE-seq and cytokine analysis. The microbiome-host interactions related with mesh exposure and the changes in protein expression will be analyzed.

Conditions

• Vaginal Microbiome
• Graft Versus Host Reaction

Timeline

• Start date: 2021-09-01
• Primary completion: 2023-09-01
• Completion: 2024-09-01
• First posted: 2021-08-11
• Last updated: 2021-09-27