NCT04998617

Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Purpose: To investigate the short-term clinical effect of curcumin-containing toothpaste on halitosis as compared to placebo and to assess potential shifts in the composition of dental biofilm associated with the use of curcumin-containing toothpaste Participants: This clinical study will 30 adult participants under prophylactic or periodontal maintenance protocol. Procedures (methods): Participants will be included and throughout the protocol will not allow the use any other oral hygiene products except standard manual toothbrush and study toothpaste (either test -curcumin-containing or placebo). Additionally participants will be instructed to odiferous foods such as onions, garlic and spices. At each of the three examination sessions, Plaque Index (six sites, O'Leary) and volatile sulphur compounds (VSC) will be measured.

Conditions

• Halitosis

Interventions

Type	Name	Description
OTHER	Toothpaste with curcumin	Subjects will be given toothpaste to be used during this study with 0.5% curcumin
OTHER	Toothpaste without curcumin	Subjects will be given toothpaste to be used during this study without curcumin

Timeline

• Start date: 2022-05-24
• Primary completion: 2023-05-05
• Completion: 2023-05-05
• First posted: 2021-08-10
• Last updated: 2023-08-09

Locations

1 site across 1 country: United States