NCT04998175

Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)

Multi-omics Research of Prognostic Factors of Ventriculoperitoneal Shunt for Idopathic Normal Pressure Hydrocephalus

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research

Detailed description

Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump. Methods- The primary methods used are: 1. The cerebrospinal fluid proteomic analysis of iNPH patients before and after VP shunt surgery. 2. The structral and functional MRI analysis of iNPH patients 3. The clinical assessment of MMSE, gait scores, Kiefer score, and mRS. Objective- To study the prognostic factors of VP shunt for iNPH.

Conditions

• Idiopathic Normal Pressure Hydrocephalus

Interventions

Type	Name	Description
PROCEDURE	ventriculo-peritoneal shunt	A ventriculoperitoneal shunt is a tube that drains excess cerebrospinal fluid into abdomen

Timeline

• Start date: 2020-09-15
• Primary completion: 2022-12-30
• Completion: 2022-12-30
• First posted: 2021-08-10
• Last updated: 2021-08-10

Locations

1 site across 1 country: China