NCT04997525

Estradiol and Progesterone Levels Following Frozen Embryo Transfer

Estradiol and Progesterone Levels in Early Pregnancy After Natural, Estradiol + Progesterone or Gonadotrophin Stimulated Frozen Embryo Transfer Cycle

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 305 (actual)
• Sponsor: Copenhagen University Hospital at Herlev · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to investigate serum estradiol and progesterone levels in women conceiving after natural, estradiol + progesterone or gonadotropin stimulated frozen embryo transfer (FET) cycles.

Detailed description

Enrolled women will be randomized based on their ovulation pattern. Ovulatory women will be randomized to either natural cycle or estradiol + progesterone substituted cycle treatment for FET. Anovulatory women will be randomized to either estradiol + progesterone substituted cycle or gonadotropin stimulated cycle treatment for FET. Included women will undergo blood testing every two weeks for serum estradiol and progesterone levels until gestational age 9+6. Routine vaginal ultrasounds will be performed as well as additional pregnancy ultrasounds. Secondary obstetric outcomes will be investigated using the womens medical journals. All the treatments are considered standard treatments for FET.

Conditions

• Infertility

Interventions

Type	Name	Description
DRUG	Estradiol Tablets	Combined with progesterone
DRUG	Progesterone	Combined with estradiol
DRUG	Follitropin Alfa	Combined with hCG
DRUG	Chorionic Gonadotropin, Alpha	In either natural cycle or combined with Follitropin Alfa

Timeline

• Start date: 2021-04-20
• Primary completion: 2024-05-07
• Completion: 2024-12-06
• First posted: 2021-08-09
• Last updated: 2025-01-03

Locations

1 site across 1 country: Denmark