NCT04991662

Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery

Effect of Three Weight-adjusted Vasopressors for With Combined Spinal-Epidural Anesthesia for Elective Cesarean Delivery: A Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Xuzhou Medical University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study compared the effects of prophylactic infusion of metaraminol, phenylephrine and norepinephrine adjusted according to body weight on fetal acid-base balance and maternal hemodynamics.

Detailed description

At present, the ED90 of metaraminol, phenylephrine, and norepinephrine in the prevention of cesarean section hypotension has been explored. We compare the effects of three drugs on the fetus and mothers at the concentration of ED90 to provide advice on the use of vasoactive drugs for obstetrics anesthesia .

Conditions

• Cesarean Section Complications

Interventions

Type	Name	Description
DRUG	metaraminol	Infusion of metaraminol adjusted according to body weight to obtain higher pH value of fetal umbilical artery blood.
DRUG	Phenylephrine	Infusion of Phenylephrine adjusted according to body weight to obtain higher pH value of fetal umbilical artery blood.
DRUG	Norepinephrine	Infusion of Norepinephrine adjusted according to body weight to obtain higher pH value of fetal umbilical artery blood.

Timeline

• Start date: 2021-10-10
• Primary completion: 2021-12-03
• Completion: 2021-12-03
• First posted: 2021-08-05
• Last updated: 2021-12-30

Locations

1 site across 1 country: China