NCT04986826

Exercise Effect on Transthyretin Stability

Exercise Effect on Transthyretin Stability in Master Athletes and Patients With Transthyretin Amyloidosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 24 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The goal of this study to investigate if exercise predisposes to transthyretin instability. The investigators will evaluate the effect of exercise on transthyretin biochemistry.

Detailed description

This is an investigator initiated observational study, designed to study the effect of exercise on transthyretin stability in three main populations: Group 1: healthy master athletes who are 60 years or older. Group 2: Genotype positive (G+) cardiac phenotype negative (P-) patients with variant ATTR (i.e. carriers without evidence of disease). Group 3: Patients with ATTR CA who have not been on a stabilizer (tafamidis) within the last 14 days prior to enrollment.

Conditions

• Amyloidosis Transthyretin
• Athlete Heart

Timeline

• Start date: 2021-07-15
• Primary completion: 2021-11-30
• Completion: 2021-12-30
• First posted: 2021-08-03
• Last updated: 2021-08-03

Locations

1 site across 1 country: United States