NCT04986410

Quantitative Analysis of Functional CT Imaging of Coronary Atherosclerosis

Quantitative Analysis of Functional Computed Tomography (CT) Imaging of Coronary Atherosclerosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 640 (actual)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this prospective observational study is to evaluate the diagnostic and prognostic performance of a "one-stop" comprehensive coronary artery anatomy and function assessment for CAD.

Detailed description

Coronary CT angiography (CCTA) has become a reliable diagnostic technique to evaluate coronary artery disease (CAD) with high sensitivity and a negative predictive value. However, CCTA provides only anatomic information and tends to overestimate stenosis severity and is limited in its ability to diagnose myocardial ischemia. Undertaking additional CT myocardial perfusion imaging(CT-MPI) and CT-FFR improves specificity and positive predictive value, reducing unnecessary invasive coronary angiography. The purpose of this prospective observational study is to evaluate the diagnostic and prognostic performance of a "one-stop" comprehensive coronary artery anatomy and function assessment for CAD. SPECT myocardial perfusion imaging (SPECT-MPI)and invasively measured fractional flow reserve (FFR) will serve as the reference standard.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CCTA, CT-MPI, CT-FFR, SPECT-MPI	Subjects undergo CCTA, CT-MPI, CT-FFR or SPECT-MPI

Timeline

• Start date: 2017-07-01
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2021-08-02
• Last updated: 2021-08-02

Locations

1 site across 1 country: China