NCT04983849

Evaluation of Metronidazole Hydrogel 25% in Stage II and III Periodontitis

Evaluation of Effects of Subgingival Administration of Metronidazole Hydrogel 25% in Stage II and III Periodontitis: Randomized, Split Mouth, Single-blind Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of L'Aquila · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A randomized clinical trial will be performed single-blind to evaluate the effectiveness of sublingual metronidazole hydrogel 25 % in periodontitis.

Detailed description

A randomized clinical trial will be performed single-blind to evaluate the effectiveness of sublingual metronidazole hydrogel 25 % in periodontitis in stage II and III. At least 40 volunteers between the age of 18 and 80, will be enlisted, with the need to perform the SRP. In half of the mouth will be used the metronidazole hydrogel 25%, while in the other half no drugs will be used of delivered. The study will be carried out in accordance with the Helsinki Declaration and the Protocol will be submitted to the Internal Review Board of the University to obtain authorization. Afterwards, the protocol will be recorded on the databa-se clinicaltrials.gov for clinical trials. The protocol respects the SPIRIT parameters for the compilation of protocols on clinical trials and the study will respect the parameters of CONSORT sta-tement on randomized clinical trials.

Conditions

• Periodontitis

Interventions

Type	Name	Description
DRUG	metronidazole hydrogel	scaling and root planning in adjunct to the use of metronidazole in the periodontal pocket
PROCEDURE	scaling and root planning	scaling and root planning

Timeline

• Start date: 2021-07-07
• Primary completion: 2021-07-07
• Completion: 2021-07-07
• First posted: 2021-07-30
• Last updated: 2023-12-12

Locations

1 site across 1 country: Italy