NCT04981093

Effect of Dexamethasone on Postoperative Inflammatory Factors

Effect of Dexamethasone on Postoperative Inflammatory Factors in Elderly Patients Undergoing Lunmbar Spine Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: General Hospital of Ningxia Medical University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.

Detailed description

A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results

Conditions

• Inflammation

Interventions

Type	Name	Description
DRUG	Dexamethasone Injection	Intravenous injection after induction of anesthesia Injection 0.15mg/kg dexamethasone (2ml)
DRUG	Normal saline	2ml of normal saline was injected intravenously after induction of anesthesia

Timeline

• Start date: 2021-08-15
• Primary completion: 2023-01-01
• Completion: 2023-12-30
• First posted: 2021-07-28
• Last updated: 2025-08-14

Locations

1 site across 1 country: China