Trials / Active Not Recruiting
Active Not RecruitingNCT04981067
Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
Median Effective Concentration of Ropivacaine for Ultrasound-guided Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- Sponsor
- Seoul National University Hospital · Academic / Other
- Sex
- All
- Age
- 19 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study was to determine the minimum effective dose of a local anesthetic for proper anesthesia for popliteal sciatic nerve block under ultrasound guidance in patients undergoing surgery for diabetic foot disease.
Detailed description
Unlike general patients, patients with diabetic foot disease often have diabetic neuropathy and thus have increased sensitivity to local anesthetics. Therefore, when performing sciatic nerve block, it is essential to properly adjust the dose to prevent neurotoxicity and delay in recovery due to local anesthetics. If the appropriate effective dose of local anesthetic for sciatic nerve block is found in patients with diabetic foot through this study, it is expected that it will be a useful basis for establishing a safe anesthetic method in the case of diabetic foot surgery.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Maintain the concentration of ropivacaine as same as those used in the previous participant | Maintain the same concentration of ropivacaine used in the previous participant with an 89% chance through a random assignment |
| OTHER | Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant | Decrease ropivacaine concentration by 0.05% from the concentration used in the previous participant with an 11% chance through a random assignment |
| OTHER | Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant | Increase ropivacaine concentration by 0.05% from the concentration used in the previous participant. |
Timeline
- Start date
- 2021-08-24
- Primary completion
- 2026-12-28
- Completion
- 2026-12-31
- First posted
- 2021-07-28
- Last updated
- 2024-11-29
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT04981067. Inclusion in this directory is not an endorsement.