NCT04977830

Pulmonary Assessment in Thoracic Insufficiency Syndrome Patients

New Strategies for Pulmonary Assessment in Spinal and Chest Wall Deformity

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Patrick Cahill, MD · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

Thoracic insufficiency syndrome (TIS) is a complex condition that involves chest wall deformities that can affect normal breathing and lung growth. In most cases, children with TIS are also born with spine disorders such as scoliosis. The inability of the thorax to support normal respiration or lung growth can cause respiratory distress and even mortality. Investigators aim to validate MRI imaging sequences to use as an assessment tool for pulmonary function.

Conditions

• Thoracic Insufficiency Syndrome

Interventions

Type	Name	Description
DEVICE	Xenon-129	Patients will undergo a hyperpolarized MRI with administered Xenon gas

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-08-30
• Completion: 2026-08-30
• First posted: 2021-07-27
• Last updated: 2026-03-05

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study