NCT04974255

Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients

Does Gluten Sensitivity Play a Role in Development of Thyroiditis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 198 (actual)
• Sponsor: Diskapi Yildirim Beyazit Education and Research Hospital · Other Government
• Sex: All
• Age: 18 Years – 88 Years
• Healthy volunteers: Not accepted

Summary

Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).

Detailed description

Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).

Conditions

• Thyroid Fibrosis

Interventions

Type	Name	Description
OTHER	Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples	Examination of pathology specimen and laboratory measuring

Timeline

• Start date: 2019-05-01
• Primary completion: 2021-07-26
• Completion: 2021-07-30
• First posted: 2021-07-23
• Last updated: 2021-07-23

Locations

1 site across 1 country: Turkey (Türkiye)