NCT04972552

Watermelon/UBIQuinone Study

Watermelon/UBIQuinone Study (WUBI-Q Trial)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of the proposed pilot trial is to determine the feasibility and safety of increasing watermelon consumption, with or without coenzyme Q supplementation in patients after kidney transplantation on kidney function and urinary protein excretion.

Detailed description

While many observational studies have examined the effects of consuming watermelon in patients without chronic kidney disease, there have been few studies on the consumption of a diet high in watermelon as a means of improving kidney function or reducing protein in the urine. Coenzyme Q is also recognized as a supplement that has benefits for heart health and has anti-oxidative effects, but whether it could be used to improve kidney function or reduce protein in the urine has not been thoroughly examined, especially in the kidney transplant population. The objective of the proposed pilot trial is to determine the feasibility and safety of increasing watermelon consumption, with or without coenzyme Q supplementation in patients after kidney transplantation.

Conditions

• Kidney Transplantation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	coenzyme Q10	Participants will take 800-1200 mg of coenzyme Q10 capsule per day
OTHER	Watermelon diet	Participants will be asked to eat watermelon at a minimum of one meal per day 3-5 days a week
OTHER	Usual Diet	Participants will be asked to eat a usual diet but not eat any watermelon as part of their usual diet
OTHER	Placebo	Participants will be asked to take 800-1200 mg of a placebo capsule per day

Timeline

• Start date: 2021-11-15
• Primary completion: 2025-12-30
• Completion: 2026-06-30
• First posted: 2021-07-22
• Last updated: 2025-07-14

Locations

1 site across 1 country: United States