Trials / Completed
CompletedNCT04972383
Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis
A Prospective,Double-Blind Randomized Controlled Trial Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Progression of Structural Changes in Knee Osteoarthritis
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 116 (actual)
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital · Academic / Other
- Sex
- All
- Age
- 50 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
To compare the efficacy and structural change of intraarticular single platelet-rich plasma(PRP) versus novel crosslinked Hyaluronic Acid(HA)(HyajointPlus) for the treatment of early stage knee osteoarthritis(OA). This was a prospective, double-blind, RCT with an allocation ratio of 1:1.
Detailed description
In the PRP group, an Aeon Acti-PRP set was used and an approximately 4-mL PRP volume was yielded and was used in a single-dose treatment. In the HA group, HYAJOINT Plus containing 60 mg of purified sodium hyaluronate was used in a single-dose treatment. All PRP and HA injection syringes were covered with opaque envelop, and the intra-articular injection procedure was performed by the same physician without ultrasound or other imaging guidance.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| COMBINATION_PRODUCT | Platelet Rich Plasma | In the Platelet Rich Plasma group, 4mL Platelet Rich Plasma was given. |
| COMBINATION_PRODUCT | Hyaluronic Acid | In the Hyaluronic group, 3mLHYAJOINT Plus was given. |
Timeline
- Start date
- 2017-11-07
- Primary completion
- 2019-10-16
- Completion
- 2019-10-16
- First posted
- 2021-07-22
- Last updated
- 2023-10-10
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT04972383. Inclusion in this directory is not an endorsement.