NCT04971447

Extracellular Vesicles and Endothelial Function in Transgender Subjects

Effects of Plasma Extracellular Vesicles on Endothelial Function in Transgender Subjects

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years – 49 Years
• Healthy volunteers: Not accepted

Summary

Cardiovascular diseases are the leading cause of mortality. In women, the prevalence of cardiovascular diseases is lower and the presentation of coronary events often atypical. The lack of evidence is related in part to the methodology of studies not considering sex as an essential biological variable. Hormonal treatment is prescribed in transgender subjects to promote the development of sexual characteristics of the desired sex. Early cardiovascular effects of hormonal treatment have been reported in transgender men, while long-term mortality is higher in transgender women. The aim of this project is to study the effects of gender affirming hormonal treatment on arterial stiffness in young transgender subjects followed at the University Hospital of Nancy.

Conditions

• Transgenderism

Interventions

Type	Name	Description
DRUG	gender affirming hormonal treatment in transgender men	testosterone enanthate
DRUG	gender affirming hormonal treatment in transgender women	GnRH agonists + estrogen

Timeline

• Start date: 2022-08-01
• Primary completion: 2023-09-01
• Completion: 2024-01-01
• First posted: 2021-07-21
• Last updated: 2022-07-25