NCT04971096

Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Mackay Memorial Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study is to evaluate whether the consumption of probiotics can improve the symptoms of patients with mild cognitive impairment; also evaluate the effects of probiotics on patients' blood, oxidation and stress related indicators.

Detailed description

Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of normal aging and the more serious decline of dementia. It can involve problems with memory, language, thinking and judgment that are greater than normal age-related changes. Probiotics are regarded as active microorganisms. When consumed in sufficient amounts, participants can regulate intestinal flora, intestinal permeability, inflammation and antioxidant reactions in the body, and may produce host health, including delaying disease and regulating metabolic disease progression and prevent complications.

Conditions

• Mild Cognitive Impairment (MCI)

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	PS23 live	PS23 belongs to Lactobacillus paracasei group.Probiotic capsules contain 30 billion CFU (colony forming units) of PS23
DIETARY_SUPPLEMENT	PS23 heat-treated	The PS23 heat-treated probiotic capsule contain 30 billion of PS23 cells.
DIETARY_SUPPLEMENT	Placebo	The placebo capsule contains microcrystalline cellulose.

Timeline

• Start date: 2022-04-01
• Primary completion: 2024-01-16
• Completion: 2024-01-16
• First posted: 2021-07-21
• Last updated: 2025-08-08

Locations

1 site across 1 country: Taiwan