NCT04967599

Alcohol Metabolism and Disease Risk in Asians

Alcohol Metabolism and Disease Risk in Asians: Examining the Impact of Personalized Phenotypic/Genotypic Feedback and Motivational Processes on Early Drinking Trajectories

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 360 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 17 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of acetaldehyde. The variant ALDH2\*2 allele is associated with the flushing response (i.e., Asian glow) and is found almost exclusively in individuals of east Asian descent. Although having variant ALDH2 alleles is protective against heavy drinking and alcohol use disorders, for those who do drink, these variants also are associated with elevations in risk for several health problems. The premise of this study is that we can affect early drinking behavior through personalized communication about these health-related risks.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	Phenotype Feedback Intervention	Online session providing information on health-related risk associated with alcohol consumption and alcohol metabolism gene variations plus personalized feedback on flushing phenotype and associated risks.
BEHAVIORAL	Genotype Feedback Intervention	Online session providing personalized feedback on alcohol metabolism genotypes and associated health-related risks.

Timeline

• Start date: 2021-08-18
• Primary completion: 2023-01-18
• Completion: 2023-01-18
• First posted: 2021-07-19
• Last updated: 2024-12-24
• Results posted: 2024-12-24

Locations

1 site across 1 country: United States