NCT04963127

Prospective Study of Diagnostic Accuracy of Spectral CT for the Detection of Bone Marrow Edema

Prospective Observational Study of Diagnostic Accuracy of Dual-Energy-/Multi-Energy-CT for the Detection of Bone Marrow Edema

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: University Hospital Augsburg · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Dual-Energy/Multi-Energy/Spectral-CT can visualize bone marrow edema associated with fractures, however, current scientific evidence is mostly derived from to retrospective analyses. Our prospective study systematically analyzes the diagnostic accuracy of the visualization of bone marrow edema by including patients who are scheduled for a CT scan to exclude or further characterize a fracture. After giving informed consent, the CT scan will be performed using a dose-neutral Dual-Energy-/Multi-Energy-/Spectral-CT acquisition technique. If the patient undergoes MRI of the same region within 7 days, this scan will be used as a gold-standard for bone marrow edema. This will allow the quantification of diagnostic accuracy.

Conditions

• Fractures, Bone
• Bone Marrow Edema

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Computed Tomography of the skeleton using a Dual-Energy-/Multi-Energy-/Spectral acquisition mode	CT acquisition using a Dual-Energy / Multi-Energy / Spectral acquisition mode
DIAGNOSTIC_TEST	Computed Tomography of the skeleton using a conventional single-energy / non-spectral acquisition mode	CT acquisition using a standard single energy / non-spectral acquisition mode

Timeline

• Start date: 2021-07-15
• Primary completion: 2025-05-31
• Completion: 2025-05-31
• First posted: 2021-07-15
• Last updated: 2023-11-22

Locations

1 site across 1 country: Germany