Trials / Unknown
UnknownNCT04963101
RNA-seq Analysis of PBMC in Patients With OPLL
Characteristics of Transcriptome Expression Profile of PBMCs in Patients With Ossification of the Posterior Longitudinal Ligament
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (estimated)
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- —
Summary
In this study, we planned to identify transcriptome expression profiles (circRNAs, lncRNAs, and mRNAs) from peripheral blood mononuclear cells (PBMCs) of 30 patients with OPLL and 30 other non-OPLL patients by high-throughput sequencing.Sequence analysis was used to predict miRNAs that might bind circRNAs and lncRNAs.Through bioinformatics analysis, competitive endogenous RNAs (cerRNAs), as well as coexpression networks among circRNAs, lncRNAs, miRNAs, and mRNAs, were constructed to provide key molecules and signaling pathways associated with OPLL.
Conditions
Timeline
- Start date
- 2021-06-25
- Primary completion
- 2022-06-25
- Completion
- 2022-06-30
- First posted
- 2021-07-15
- Last updated
- 2021-07-15
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04963101. Inclusion in this directory is not an endorsement.