NCT04961502

Humoral and Cellular Responses to Vaccination Against Coronavirus Disease 2019 (COVID-19) in the Very Elderly Living in Geriatric Institutions

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Gérond'if · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main objective of this study is to describe the humoral and cellular response to BNT162b2 vaccination in people over age 75 institutionalized in the long-term care units of the Paris Public Hospitals (APHP)

Detailed description

This is an interventional study with minimal risk and constraints, multicenter with biological collection. Two populations are studied: patients and members of care staff. The following data will be collected: * For patients and staff: age, gender, existence of Coronavirus Disease 2019 (COVID-19) infection and whether or not it is symptomatic and date of first positive RT-PCR test, medical history * For patients: nutritional status (loss of appetite, weight loss, body mass index, albuminemia) Vaccination antibodies are measured using 3 blood sample: The first carried out before the anti-Coronavirus Disease 2019 (COVID-19) vaccination; the second on D21 (shortly before the vaccination booster injection) and the third on D50-54. In addition, during the first sample, assays will be carried out informing us of your nutritional and inflammatory status.

Conditions

• Elderly People Institutionalized in Long-term Care Services

Interventions

Type	Name	Description
BIOLOGICAL	Blood test to describe the humoral and cellular response to vaccination BNT162b2 in the elderly	3 blood samples taken to compare the immunization response of the elderly with that of younger adults (priority caregivers): the first carried out before the anti-Coronavirus Disease 2019 (COVID-19) vaccination; the second shortly before the vaccination booster injection and the third approximately two months after the first vaccine injection

Timeline

• Start date: 2021-03-11
• Primary completion: 2021-08-01
• Completion: 2021-09-01
• First posted: 2021-07-14
• Last updated: 2021-07-14

Locations

1 site across 1 country: France