NCT04957277

Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 5 Years – 19 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy during stepping tasks.

Detailed description

Individuals with bilateral cerebral palsy (BCP) sustain a neonatal brain injury that leads to altered neuromuscular control to the lower limbs. One commonly observed motor impairment from this altered control is loss of selective voluntary motor control (SVMC), defined as the ability to independently move the joints intentionally. Loss of SVMC typically manifests as knee and ankle joint impairment and abnormal coupling between the hip adductors and lower limb extensors. This can make stepping up or down a curb or stair challenging, but quantitative investigation in these closed-chain activities has been limited. This is especially important as performance in stair-climbing is associated with limitations to overall mobility and community participation in cerebral palsy. The overall aim of this proposal is to investigate the altered neuromuscular control that challenges stair walking in individuals with BCP. Participants who consent to the study will be instructed to perform multiple step-ups and step-downs on a single raised platform. The parameters of the stepping task may change by adding weight to the body or subtracting weight from the body. Using standard gait analysis techniques, biomechanical metrics such as joint kinematics and kinetics will be analyzed.

Conditions

• Cerebral Palsy
• Bilateral Cerebral Palsy
• Diplegic Cerebral Palsy

Interventions

Type	Name	Description
OTHER	load modulation	Adding body weight (BW) up to 20% BW and subtracting body weight down to -20% BW

Timeline

• Start date: 2021-05-19
• Primary completion: 2024-06-01
• Completion: 2025-06-01
• First posted: 2021-07-12
• Last updated: 2024-03-15

Locations

1 site across 1 country: United States