NCT04953195

Thyroid Replacement Therapy in Patients With Subclinical Hypothyroidism

Effect of Thyroid Replacement Therapy on Thyroid Structure in Patients With Subclinical Hypothyroidism

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Beijing Chao Yang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this experiment is to compared the changes of thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping and various metabolic indexes from baseline to the end of treatment (after the thyroid function had been normal for more than three months)

Detailed description

In patients with autoimmune thyroiditis with mild subclinical hypothyroidism, the study period will include a screening period of not more than 30 days, and a 12-week treatment period compared to baseline. At completion of treatment, Thyroid Stimulating Hormone(TSH), free thyroxine (FT4)，free thyroxine (FT3) will be included. The changes of anti-thyroglobulin antibody, anti-thyroglobulin antibody, T1-mapping and metabolic indexes.

Conditions

• Subclinical Hypothyroidisms

Interventions

Type	Name	Description
DRUG	Levothyroxine Sodium Tablets	Levothyroxine Sodium(50ug/Tablets,dosage form 25ug,once a day) was administered to patients with autoimmune thyroiditis with mild subclinical hypothyroidism,

Timeline

• Start date: 2019-01-01
• Primary completion: 2021-09-15
• Completion: 2021-10-30
• First posted: 2021-07-07
• Last updated: 2021-07-07

Locations

1 site across 1 country: China