NCT04952870

Perinatal Covid-19 Infection, NO Pathway, and Minipuberty

Exploratory Multicenter Observational Study to Assess the Outcome of Infants With Perinatal SARS-COV-2 Infection and Its Link With the NO Pathway: the Minipuberty Hypothesis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 180 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 3 Months
• Healthy volunteers: Not accepted

Summary

Some evidence exists that SARS-COV-2 may infect pituitary axis, and therefore may alter hypothalamic function. Whether perinatal COVID-19 is associated with alterations in the maturation of the Hypothalamic-Pituitary-Gonadal (HPG) axis, and specifically with its transient activation occurring during infancy, namely minipuberty, is a major concern. Among the various pathogenic features related to COVID-19, altered minipuberty could be a key factor underlying many multimorbidities later in life, suggesting that they could involve a common causative mechanism that occurs within this short and critical period of time following birth. Altered minipuberty together with NO deficiency seem to be key factors underlying many of these multimorbidities, suggesting that they involve a common causative mechanism that occurs within this short and critical period of time following birth

Conditions

• Newborn, Infant, Disease
• Neurodevelopmental Disorders

Interventions

Type	Name	Description
OTHER	Inhaled NO	Newborn or young infants (\< 3 months) receiving inhaled NO as part of their treatment for severe respiratory failure
OTHER	routine care	Patients treated for respiratory failure

Timeline

• Start date: 2022-11-03
• Primary completion: 2026-11-01
• Completion: 2026-11-01
• First posted: 2021-07-07
• Last updated: 2023-02-08

Locations

2 sites across 2 countries: France, Greece