NCT04950153

Intensive Combination Approach to Rollback the Epidemic in Nigerian Adolescents: UH3 Phase

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 558 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 15 Years – 24 Years
• Healthy volunteers: Accepted

Summary

Combination interventions with mHealth and Peer Navigation components will be evaluated in a randomized, stepped wedge trial among youth in Ibadan, Lagos, Sagamu, and Jos, Nigeria. Study findings will demonstrate whether or not the combination interventions for HIV testing and linkage to care and for HIV treatment outcomes, which were found to be efficacious in our prior pilot UG3 trial, will remain efficacious if scaled as proposed in this UH3 trial, across multiple sites.

Detailed description

A randomized stepped wedge (cluster) trial will be conducted to investigate two combination interventions (each with mHealth + Peer Navigation components) among youth in Ibadan, Lagos, Sagamu, and Jos, Nigeria. Study 1 (Testing and Linkage to Care) will test a combination intervention that targets HIV testing and linkage to care. Study 2 (Treatment Intervention) will test a combination intervention that targets HIV treatment outcomes (retention, adherence and viral suppression).

Conditions

• Adolescent HIV Infection

Interventions

Type	Name	Description
BEHAVIORAL	Peer navigation	Peer navigators will navigate youth with HIV to provide assistance and support to optimize adherence to antiretroviral treatment (ART)
BEHAVIORAL	SMS Text messaging	Short Message System (SMS) text messages to remind and encourage youth to adhere to their ART
BEHAVIORAL	Social Media Engagement	HIV testing outreach using social media platforms to promote HIV testing.
BEHAVIORAL	Testing Peer Navigation	Peer navigators will conduct HIV testing outreach and linkage to care to at-risk youth

Timeline

• Start date: 2021-04-15
• Primary completion: 2024-08-30
• Completion: 2024-12-31
• First posted: 2021-07-06
• Last updated: 2024-10-15

Locations

6 sites across 1 country: Nigeria