NCT04950049

The Effect of Dilution and Prolonged Injection Time on Dexamethasone-induced Perineal Irritation

The Effect of Dilution With Glucose and Prolonged Injection Time on Dexamethasone-induced Perineal Irritation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: General Hospital of Ningxia Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the efficacy of dilution with glucose and prolonged injection time on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).

Detailed description

Dexamethasone is a synthetic glucocorticoid, which may cause perineal irritation when given intravenously. The major clinical manifestations are pruritus and pain，and the incidence vary between 38%-71%. Some patients undergo spontaneous remission, while others develop into severe pain or pruritus. In clinical practice, dexamethasone is always diluted with glucose in many cases, but diluted dexamethasone in relieving dexamethasone induced perineal irritation has not been studied yet. The aim of this study was to investigate the efficacy of dilution with glucose on dexamethasone induced perineal irritation.

Conditions

• Adverse Effect

Interventions

Type	Name	Description
DRUG	Dexamethasone	receive 2ml dexamethasone (5mg/ml)
OTHER	Diluted dexamethasone 5ml	receive 5ml dexamethasone (2mg/ml) diluted with 5% glucose
OTHER	Diluted dexamethasone 10ml	receive 10ml dexamethasone (1mg/ml) diluted with 5% glucose
OTHER	Diluted dexamethasone 20ml	receive 20ml dexamethasone (0.5mg/ml) diluted with 5% glucose

Timeline

• Start date: 2021-07-15
• Primary completion: 2021-08-31
• Completion: 2021-08-31
• First posted: 2021-07-06
• Last updated: 2021-07-06