NCT04938947

Resistance Training and Blood Flow Restriction

Effect of Resistance Training With Blood Flow Restriction on Motor Unit Hypertrophy in the Vastus Lateralis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: University of Kansas · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The primary purposes of the proposed study is 1) To examine the changes of muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction and 2) To examine changes in motor unit size (a non-invasive measure of muscle fiber size) in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction.

Detailed description

Specific Aims and Hypotheses: Specific Aim 1: To examine the changes of type I and II (different types of muscle fibers) muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 1: Type I and II fiber cross-sectional area will increase following low-intensity resistance training with blood flow restriction, however, only cross-sectional area of type II fibers will increase post high-intensity resistance training. Specific Aim 2: To examine changes in the size of the motor units that are active during low and high intensity contractions in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 2: The motor units that are active during low and high intensity contractions will increase in size from low-intensity resistance training with blood flow restriction, but only the motor units that are active during high intensity contractions will increase in size from high-intensity resistance training. Specific Aim 3: To examine changes in whole muscle cross-sectional area as measured via ultrasound pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 3: Whole muscle cross-sectional area will increase to similar degrees from both high-intensity resistance training and low-intensity resistance training with blood flow restriction.

Conditions

• Blood Flow Restriction and Low-Intensity Resistance Training

Interventions

Type	Name	Description
DEVICE	Blood Flow Restriction Cuffs	This intervention consists of inflatable cuffs that are designed to partially occlude veinous blood return from the lower extremities during resistance training.
OTHER	Low-Intensity Resistance Training	This intervention consists of performing low-intensity bilateral (both legs at the same time) leg extensions using 30% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.
OTHER	High-Intensity Resistance Training	This intervention consists of performing high-intensity bilateral (both legs at the same time) leg extensions using 80% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.

Timeline

• Start date: 2021-09-22
• Primary completion: 2022-02-15
• Completion: 2022-02-15
• First posted: 2021-06-25
• Last updated: 2022-11-01

Locations

1 site across 1 country: United States