NCT04933604

LPN in Patients With High-complex Renal Tumors

Comparison of Laparoscopic Partial Nephrectomy Versus Laparoscopic Radical Nephrectomy in Patients With High-Complexity Renal Tumors: A Propensity Score Matched Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 78 (actual)
• Sponsor: Samsun Liv Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The study aims to investigate the rationale for LPN in patients with high-complexity renal tumors in terms of oncologic and functional outcomes.

Detailed description

From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and 265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus (DM), hypertension (HT), coronary artery disease (CAD), and final tumor pathology of RCC) was used to reduce selection bias. Functional and oncological outcomes were compared between the two groups. After propensity score analysis, 39 patients in the LRN group were matched with 39 in the LPN group.

Conditions

• Renal Cancer
• Renal Neoplasm
• Renal Cell Carcinoma
• Surgery
• Oncology
• Kidney Ischemia
• Kidney Injury
• Urologic Neoplasms
• Urologic Cancer
• Kidney Neoplasms

Interventions

Type	Name	Description
PROCEDURE	laparoscopic partial nephrectomy	Nephron sparing minimally invasive surgery
PROCEDURE	Laparoscopic radical nephrectomy	Completely removal of kidney by using laparoscopic surgery

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-05-30
• Completion: 2021-02-04
• First posted: 2021-06-22
• Last updated: 2021-06-22

Locations

1 site across 1 country: Turkey (Türkiye)