NCT04931628

Efficacy and Safety of Salvianolic Acid on AIS

Efficacy and Safety of Salvianolic Acid on Acute Ischemic Stroke

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Stroke has the characteristics of high morbidity, disability and fatality rate, which brings heavy spiritual and economic burdens to the family, society and the country. In my country, 33%-50% of ischemic strokes are attributed to intracranial atherosclerosis. Studies have shown that oxidative stress, increased blood viscosity, and damage to vascular endothelial cells are important mechanisms for the development of cerebral infarction. Salvia miltiorrhiza is a commonly used traditional Chinese medicine in traditional medicine in my country. Salvia miltiorrhiza polyphenolic acid is the effective ingredient of salvia miltiorrhiza. It is the water-soluble active part of salvia miltiorrhiza. It can resist oxidation, anticoagulation, antiplatelet, cell protection, and expand blood vessels, thereby achieving protection Cardiovascular system. The purpose of this study was to evaluate the effects and adverse effects of salvianolic acid on acute ischemic stroke onset within 72 hours, and to evaluate the improvement of patients' ischemic area perfusion and clinical function scores.

Conditions

• Stroke

Interventions

Type	Name	Description
DRUG	Salvianolic Acid	salvianolic acid, injection, 100mg+0.9%NaCl 250ml, qd, 14 days
DRUG	0.9% NaCl	0.9% NaCl

Timeline

• Start date: 2023-02-03
• Primary completion: 2023-02-03
• Completion: 2023-02-03
• First posted: 2021-06-18
• Last updated: 2023-02-06

Locations

1 site across 1 country: China