NCT04930224

Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients

Comparing the Impact of Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients and Healthy Individuals: A Pilot Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Kahramanmaras Sutcu Imam University · Academic / Other
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Observational, comparative, cross-sectional study

Detailed description

This study was conducted on G protein-mediated estrogen receptor 1 (GPER-1), which is thought to be effective in preventing the development of diabetic retinopathy (DR). There are studies proving that GPER-1 prevents neuroprotective effects and vascular pathology in many tissues. In the study, serum GPER-1 and oxidative stress biomarker levels were compared in diabetic patients and healthy control groups. GPER-1 was found to be significantly increased in diabetic patients. In addition, a positive correlation was found with oxidant markers. This may lead to new treatment models in the future.

Conditions

• Diabetes Mellitus
• Diabetic Retinopathy
• Hormones

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The effect of GPER-1 on the formation of diabetic retinopathy	Demonstrating the neuroprotective effect of GPER-1 in the formation of diabetic retinopathy and being a guide for new treatment models

Timeline

• Start date: 2019-07-01
• Primary completion: 2020-01-31
• Completion: 2020-04-25
• First posted: 2021-06-18
• Last updated: 2021-06-23

Locations

1 site across 1 country: Turkey (Türkiye)