NCT04929002

Carbon-13 Magnetic Resonance Spectroscopy in Glycogen Storage Diseases

Using Carbon-13 Magnetic Resonance Spectroscopy to Assess Whether High Glycogen Levels in Skeletal Muscle of Patients With Glycogen Storage Diseases is a Prelude for Muscle Damage.

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The project will use carbon-13 magnetic resonance spectroscopy to assess whether high glycogen levels in skeletal muscle of patients with Glycogen Storage Diseases is a prelude for muscle damage. Patients with Glycogen Storage Diseases will be examined using carbon-13 MR-spectroscopy to quantify the glycogen levels in lumbar, thigh and calf-muscles. The pattern of glycogen concentration will be compared to the pattern of muscle atrophy found in the literature.

Conditions

• Glycogen Storage Disease
• McArdle Disease
• Pompe Disease (Late-onset)

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2021-12-10
• Primary completion: 2028-05-01
• Completion: 2028-12-01
• First posted: 2021-06-18
• Last updated: 2025-08-11

Locations

1 site across 1 country: Denmark