NCT04928300

Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs

Diaphragmatic Function, Pain Quality & Anti-inflammatory Properties: A Low Dose Dexmedetomidine Versus Ketamine in Patients With Multiple Fracture Ribs Needing Conservative Treatment

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.

Detailed description

A written informed consent from patients or thier legal guardians, Patients will be assigned randomly to two groups (30 subjects each) with traumatic multiple fracture ribs 3 ribs or more. After thoracic epidural is inserted, the drug study intervention will be started and run for 5 days during ICU admission. In (Group D) low dose dexmedetomidine infusion 0.2 µ/kg/hour IV for 5 days. In (Group C) the same dose and duration of normal saline will be given.

Conditions

• Rib Fractures

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	low dose dexmedetomidine infusion 0.2 µ/kg/hour IV for 5 days.
OTHER	0.9% saline	the same dose and duration of normal saline will be given for 5 days.

Timeline

• Start date: 2021-06-12
• Primary completion: 2027-07-01
• Completion: 2027-07-25
• First posted: 2021-06-16
• Last updated: 2026-01-02

Locations

1 site across 1 country: Egypt