NCT04926961

Testing the Contribution of Orbitofrontal Cortex Networks to Reward Identity Learning

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This research study examines the contribution of orbitofrontal cortex (OFC) networks to learning reward identity expectations.

Detailed description

This study is designed to examine the contribution of OFC networks to reward identity learning. It will use network-targeted TMS to test whether OFC is necessary for reward identity learning. Healthy human subjects will perform a three-reward reversal learning task after either TMS or sham stimulation while fMRI data are acquired. This is a randomized, within-subject, cross-over study.

Conditions

• Healthy

Interventions

Type	Name	Description
DEVICE	Sham transcranial magnetic stimulation (TMS)	Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.
DEVICE	Real transcranial magnetic stimulation (TMS)	Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil.

Timeline

• Start date: 2021-06-16
• Primary completion: 2021-11-03
• Completion: 2021-11-03
• First posted: 2021-06-15
• Last updated: 2025-06-17

Locations

1 site across 1 country: United States