NCT04924530

Effect of Lactose on Blood Lipids

Revealing the Mechanisms by Which Milk Sugars Exaggerate Postprandial Lipaemia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: University of Bath · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine to what extent ingestion of free sugars influence postprandial triglyceridaemia in men and women.

Detailed description

Each participant will undergo three experimental trials in a randomized, crossover research design. On each study day, participants will consume a test drink containing standardised amounts of carbohydrate and fat followed by collection of blood and breath samples to assess metabolic responses during the 6 hour postprandial period. Trials will be identical except for the type of carbohydrate contained within the test drink: 1) maltodextrin (glucose polymer), 2) lactose (galactose-glucose disaccharide) and 3) sucrose (fructose-glucose disaccharide).

Conditions

• Cardiovascular Risk Factor
• Lipaemia
• Metabolic Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Maltodextrin	Co-ingestion of maltodextrin with a high fat meal
DIETARY_SUPPLEMENT	Sucrose	Co-ingestion of sucrose with a high fat meal
DIETARY_SUPPLEMENT	Lactose	Co-ingestion of lactose with a high fat meal

Timeline

• Start date: 2021-06-07
• Primary completion: 2022-07-13
• Completion: 2023-07-21
• First posted: 2021-06-14
• Last updated: 2024-09-23
• Results posted: 2024-09-23

Locations

1 site across 1 country: United Kingdom